Eurand’s Diffucaps® technology enables the development of once-daily controlled-release (CR) capsules or patient-friendly orally disintegrating tablet ( ODT). Download scientific diagram | ORBEXA ® Technology 3) DIFFUCAPS ® Technology: Diffucaps is a multiparticulate bead system comprised of multiple layers of. DIFFUCAPS ® technology 4) DIFFUTAB ® Technology: Diffutab technology enables customized release profiles and region-specific delivery. Diffutab.

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Trop J Pharm Res.

Recent technologies in pulsatile drug delivery systems

Further developments are therefore needed to overcome these issues, so that 3DP systems can be successfully combined with conventional pharmaceutics. In addition to this, there are no risk of dose dumping, flexibility of blending units with different release patterns, as well as short and reproducible gastric residence time. Formulation and evaluation of chronopharmaceutical drug delivery of theophylline for nocturnal asthma. Additional membranes may be added to further control release rate.

9. Pulsatile Drug Delivery System: Method and Technology Review | Insight Medical Publishing

Controlled release delivery system by an osmotic bursting mechanism. Drug release from electric current sensitive polymers. Open in a separate window. The inflamed responsive cells produce hydroxyl radicals. Diseases that require pulsatile drug delivery. Migration inhibiting additives were effective in limiting transport. OROS Technology Osmotic-controlled Release Oral delivery System This technology depends on osmotic pressure to give pre-programmed, controlled drug delivery to the gastrointestinal tract.


Verma RK, Garg S. There has been much interest in the development of a stimuli-sensitive delivery system that releases therapeutic agents in the presence of a specific enzyme or protein. In peptic ulcer acid secretion is high in the afternoon and at night.

Minitabs in multiparticulate drug delivery. Formulation and in vitro evaluation of floating pulsatile tablets of nizatidine for chronotherpy of ulcers ; 4 5: Another new approach was enteric-coated, timed-release, press-coated tablets ETP tablets.

Formulation and stastical optimization of time controlled pulsatile release propranolol hydrochloride compressed coated tablet. Implantable, polymeric systems for modulated drug delivery. Polyelectrolyte contains polymers with technologt high concentration of ionisable groups along the backbone chain.

OSDRC technology The conventional dry-coated tablet DC method requires core tablet preparation before, and therefore, the complicated procedure of the conventional DC method increases the manufacturing cost and the chance of failure, which may lead to a rise in core tablet supply.

Circadian rhythms Circadian rhythms are self-sustaining, endogenous oscillations that occur with a periodicity of about 24 Hours Figure. Bulk erosion means that the ingress of water is faster than the rate of degradation.

Significant modification and designing of the conventional delivery systems in the form of pulsatile delivery systems ensures the time-controlled pulsatile release of bioactive compounds, which is prerequisite in the treatment of such disorders. BP is at its lowest during the sleep cycle and rises steeply during the early morning.


Design difficaps evaluation of a dry coated drug delivery system with floating— pulsatile release. Related article at PubmedScholar Google. In this technology, chronotherapy diffudaps presscoated tablets are used technologt which an active drug remain surrounded by an outer tablet layer consists of a mixture of hydrophobic wax and brittle material.

Recent technologies in pulsatile drug delivery systems

etchnology Thermo responsive polymeric micelle systems: In certain cases, immediate release of drug is undesirable. Floating or pulsatile drug delivery systems based on coated effervescent cores.

Pulsatile drug delivery system. These devices also have pH sensitive hydro gel containing glucose oxidase immobilized in the hydro gel. This swelling of the polymer induced by this pH change which results in insulin release. Variations in pH throughout the GI tract affect the xiffucaps and absorption of certain drugs.

Schematic representation of different drug delivery systems where A sigmoidal release technolgy lag time B delayed release after lag time C sustained release after lag time D extended release without lag time. In this technology, pellets are coated inside of the capsule.